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In mouse xenograft models, 9x repressed tumefaction growth driven by both crazy type KIF5B-RET-Ba/F3 and gatekeeper mutant KIF5B-RET(V804M)-Ba/F3 cells in a dose-dependent manner. Together, these information establish that 9x provides a good starting place for the growth of targeted therapeutics against RET-positive cancers, specially NSCLC.The interaction between menin and mixed lineage leukemia (MLL) had been identified as a fascinating target for the treatment of some types of