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The fabricated Au-Te nanoworm exhibited an interconnected construction of small spherical nanoparticles and had been found to work at enhancing Raman scattering. The Au-Te nanoworm-immobilized substrate exhibited the capability to detect thyroxine using an aptamer-tagged DNA three-way junction (3WJ) and glycoprotein 120 (GP12 personal immunodeficiency virus (HIV) making use of an antibody. The modified substrates had been examined