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Multivariate analysis were performed to identify risk factors for POPF. The percentage of morbidity and the incidence of POPF were higher in the high-balance group compared to the low-balance group (61.6% 37.2%, P = 0.001; 15.1% 3.5%, P = 0.009). High postoperative fluid balance and the presence cardiovascular disease were correlated with POPF on multivariate analysis (odds ratio [OR], 4.574; 95% confidence interval [CI], 1.229-17.029; P = 0.023 and OR, 3.517; 95% CI, 1.209-12.017; P = 0.045). Higher amount of postoperative fluid balance
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