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Copyright © 2020 Li, Ding, Jiang, Hayat, tune, Li, Zhang and Zhang.Identifying therapies that mitigate ischemic colonic damage and improve mucosal healing and abdominal viability are very important to increasing success in horses with ≥360° big colon volvulus (LCV). Ethyl pyruvate may be the ethyl ester of pyruvate with diverse pharmacologic effects that restrict ischemic injury and hasten abdominal mucosal fix in preclinical rats, sheep and swine models. The objective of this study would be to figure out the re