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The Caco-2 cell monolayer transportation study proved that SNAC could somewhat enhance permeability of BER 2-3-fold. Pharmacokinetic studies demonstrated a 9.87-fold rise in area beneath the bend (AUC) of BER mixed with SNAC and a 14.14-fold rise in AUC of microspheres compared with BER alone. These conclusions indicate that SNAC is a promising absorption enhancer for oral distribution of BER in the shape of both option and microspheres.BACKGROUND
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