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Moreover, crystal frameworks of appropriate hydroxylases offer much insight into their particular practical roles. Since hydroxylases performing on free L-proline participate in the 2-oxoglutarate-dependent dioxygenase superfamily, mobile k-calorie burning of Escherichia coli along with a hydroxylase is a very important source of 2-oxoglutarate, which is essential as a co-substrate in L-proline hydroxylation. Further, microbial hydroxyproline 2-epimerase may act as a highly ada