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Selenium (Se) deficiency significantly impacts the cow breeding industry by reducing the milk quality of dairy cows and affecting the health of calves. The molecular mechanism of Se deficiency-induced damage to calves, however, remains unclear. The present study investigated whether Se deficiency induces oxidative stress, apoptosis, and inflammation in calf liver tissues. We collected the liver tissues of calves with Se deficiency. Experimental results showed that Se deficiency weakened the activity of antioxidant enzymes and increased t