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No severe side effects occurred. In three of four patients, everolimus led to stable disease for the longestcompared to the other nonsurgical therapies used. Comparing the sparse data available everolimus is a promising treatment for t-NEN at least in second-line therapy. A low Ki-67 index was associated with a better outcome. Comparing the sparse data available everolimus is a promising treatment for t-NEN at least in second-line therapy. A low Ki-67 index was associated with a better outcome. To evaluate a criterion for the selective