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Moreover, potent adaptive and innate immune responses were stimulated in the OMV-immunized mice. Our findings demonstrate that self-adjuvanting Y. pestis OMVs are a novel plague vaccine candidate and show that the rational design of OMVs could serve as a robust approach for vaccine development. Copyright © 2020 American Society for Microbiology.OBJECTIVE To examine recent changes in sex-specific and age-specific suicide mortality by method across countries. METHODS Using mortality data from the WHO mortality databas