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Sputum examples of 41 AECOPD patients and 26 healthier controls were gathered from Guangzhou Medical University, China. Samples had been processed for 16S rRNA gene-based microbiome profiling. Thirty clients restored with initial antibiotic treatment (antibiotic success or AS), while 11 clients revealed bad outcome (antibiotic failure or AF). Significant variations in microbiome were seen in AF versus AS patients and healthier controls. There was dramatically reduced alpha diversity and enhance