https://www.selleckchem.com/pr....oducts/NVP-AUY922.ht
Given that tNOX catalyzes the oxidation of NADH, the direct binding of capsaicin to tNOX also inhibited the NAD+-dependent activity of sirtuin 1 (SIRT1) deacetylase, we found that capsaicin-induced autophagy involved enhanced acetylation of ULK1, which is a key player in autophagy activation, possibly through SIRT1 inhibition. In p53-mutated HSC-3 cells, capsaicin triggered both autophagy and apoptosis. In , autophagy occurred before apoptosis during this early stage, autophagy seemed to inhibit apoptosis; at a later stage, in contra
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