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The rest of the seven patients received temozolomide/etoposide as adjuvant treatment following resection of relapsed metastatic disease; among these, one ended up being free from illness for 41 months. Possibly useful effects were observed in two of three O6-methylguanine-DNA methyltransferase protein-negative patients, whereas all five O6-methylguanine-DNA methyltransferase-positive patients experienced subsequent relapse. Nothing of this clients experienced serious negative effects requiring hospit