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038). In accordance with the present study, only the multiple tract punctures were associated with blood transfusion requirements in PCNL. In accordance with the present study, only the multiple tract punctures were associated with blood transfusion requirements in PCNL. The prostate cancer microenvironment is highly immunosuppressive; immune cells stimulated in the periphery by systemic immunotherapies will be rendered inactive once entering this environment. Immunotherapies for prostate cancer need to break this immune tolerance. We ha