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A 2-compartment PPK model with first-order absorption and nonlinear clearance from the central compartment described the data well. PPK identified weight as the main intrinsic factor and food as the main extrinsic factor affecting SXB PK, and predicts similar PK profiles on a mg/kg basis across ages. These results, along with previously reported efficacy and safety outcomes, support weight-based SXB dose initiation in pediatric patients. This article is protected by copyright. All rights reserved.Since 2006, the US Congress has appropri
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