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However, many of the points raised will also be worth considering for SAXS experiments of globular proteins.Small-angle X-ray or neutron scattering (SAXS/SANS/SAS) is widely used to obtain structural information on biomolecules or soft-matter complexes in solution. Deriving a molecular interpretation of the scattering signals requires methods for predicting SAS patterns from a given atomistic structural model. Such SAS predictions are nontrivial because the patterns are influenced by the hydration layer of the solute, the excluded solvent