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Thermo-mechanical load cycling was performed in a chewing simulator followed by fractural loading of the crowns. A mixed effect linear model was fitted to the data, and pairwise contrasts were estimated on the marginal means and corrected for multiple testing according to Tukey (α = 0.05). The means for fracture load (N) were 2435 N (95% CI (2162, 2709)) for hybrid ceramic, 1838 N (95% CI (1565, 2112)) for reinforced composite, 1670 N (95% CI (1396, 1943)) for human tooth and 1142 N (95% CI (868, 1415)) for polymethyl methacrylate abutm