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Results At PN17, there was no significant difference in the area of non-perfused retina between the hyperoxic control and the 100ng and 1000ng aflibercept groups. At PN25, the 100ng (p less then 0.05) and 1000ng (p=0.008) treatment group displayed less non-perfusion compared to hyperoxic controls. At the 1000ng dose, there was increased non-perfusion compared to the 100ng dose (p=0.02). There was reduced non-perfusion by PN25 compared to PN17 for the 100ng group (p less then 0.05) with no difference in the 1000ng group. Conclusions The st