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BACKGROUND Resuscitative endovascular balloon occlusion associated with the aorta (REBOA) causes physiological, metabolic, end-organ and inflammatory changes that have to be addressed for better handling of severely injured customers. The aim of this research would be to investigate occlusion time-dependent metabolic, end-organ and inflammatory results of total REBOA in Zone I in a normovolemic animal model. METHODS Twenty-four pigs (25-35 kg) were randomized to to