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Imaging-cardiopulmonary exercise examination (CPET) is a non-invasive, provocative test providing a multi-variable assessment of pulmonary, aerobic, muscular, and mobile oxidative methods during workout, with the capacity of offering unique incorporated pathophysiological information. With this specific review we aimed at defying the cardiorespiratory changes unveiled through imaging-CPET that appear specific of T2DM subjects without overt aerobic or pulmonary illness. In