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Notably, PA-treated hepatocytes exhibited increased viability (87.3 ± 2.2% vs 65.5 ± 2.5% for untreated cells), with reduced intracellular lipid accumulation reflecting promotion of lipolysis and fatty acid β-oxidation; this protective effect may depend on inhibition of both PA-induced HepG2 cell COX-2 expression and PGE2 accumulation.Excessive application of fertilizers negatively affects soil health, causes low nutrient utilization efficiency in plants, and leads to environmental pollution. The application of controlled-release fertili
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