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Two main themes of skin failure were identified through this scoping review the etiology of skin failure and the interchangeable use of definitions. Use of the term skin failure has increased significantly over the past 30 years. There remains a significant lack of empirical evidence related to skin failure and the lack of quality research has resulted in multiple definitions. These results illustrate substantial gaps in the current literature and the need for a better understanding of how skin failure develops. Use of the term skin fa