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46%). The hospitalization expenditure correlated positively with length of stay, surgery, and drug expenses (rs= 0.586-0.754, P .01) and negatively associated with age (rs=-0.074, P .01). The length of stay mediated the relationship between surgery and hospitalization expenses for patients with breast cancer. The factors that affected the hospitalization expenditure were the drug expenses, surgery, length of stay, insurance status, and institution level. The cost control for CCE of breast cancer inpatient treatment is crucial