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All vaccines rely on the ability of B cells to remember pathogen infections and respond more vigorously upon reinfection. In this issue of Cell, Viant et al. address the real-world issue of protection against rapidly emerging pathogen variants and describe how memory B cells may anticipate infections by such variants.Whittington et al. demonstrate how network architectures defined in a spatial context may be useful for inference on different types of relational knowledge. These architectures allow for learning the structure of the envi