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Delta total QOL was higher in patients whose statement about having DN changed since 2012. Over 4years, 36 patients suffered amputations. Male sex (OR=3.11, 95% CI 1.46-6.62, P=.003), physical functioning/large-fibre neuropathy subscale score (OR=1.04, 95% CI 1.001-1.09, P=.047), autonomic neuropathy subscale score (OR=0.78, 95% CI 0.64-0.94, P=.011) and small-fibre neuropathy subscale score (OR=1.21, 95% CI 1.05-1.40, P=.007) were significant predictors of amputations. Delta total QOL-DN score was 10 times higher in patients who suffe
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