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03; PFS P = 0.04). Multivariate analysis determined that perioperative second-line chemotherapy was an independent factor influencing OS (OR [95% CI] 0.468 [0.294-0.744], P = 0.001) and PFS (OR [95% CI] 0.517 [0.353-0.758], P = 0.001). Perioperative second-line chemotherapy could improve the survival of patients who underwent hepatectomy, with resectable liver metastases that occurred during or early after adjuvant chemotherapy for CRC. Perioperative second-line chemotherapy could improve the survival of patients who underwent hepatectom