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5 ± 1.8% vs controls 42.5 ± 1.5%; p = 1.. Clinical measures of disease did not correlate well with OCT-A perfusion densities (p0.05). These findings may represent decreased blood flow and subclinical ischemia to the optic nerve. We discuss possible pathogenic mechanisms of thyroid-related vasculopathy, including vessel wall thickening due to immunologically-induced media enlargement. These findings may represent decreased blood flow and subclinical ischemia to the optic nerve. We discuss possible pathogenic mechanisms of thyroid