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Differences were found in the numeric rating scale on days 2, 3, 5, and 10 and in the patient satisfaction score on PODs 5 and 10. Uni-VATS is associated with less chest pain and better patient satisfaction in the short term but without differences in complication rates or surgical margins from the lesions. University Hospital Medical Information Network Clinical Trial Registry (UMIN000015340 http//www.umin.ac.jp/english/ ). University Hospital Medical Information Network Clinical Trial Registry (UMIN000015340 http//www.umin.ac.jp/englis