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Despite several crystal structures of the chemical with all the imino- and azasugars bound in the active web site having already been fixed, the particular acid-base chemistry associated with binding isn't understood. In this study we show, using photoinduced electron transfer (dog), that 1-deoxynojirimycin and isofagomine derivatives are protonated by person acid β-glucosidase when bound even though totally unprotonated away from enzyme. While isofagomine derivative protonation to some extent ended up being foreshadowed by previous crystal struc
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