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021). Workload-corrected pulmonary capillary wedge pressure normalized to body weight (PCWL) was higher in AdHF patients compared with non-advanced (112±55 vs. 86±49mmHg/W/kg, P=0.04). Further, AdHF patients had a smaller increase in cardiac index during exercise (1.1±0.7 vs. 1.6±0.9L/min/m , P=0.028). A significantly higher PCWL and lower cardiac index reserve during exercise were observed in AdHF patients compared with non-advanced. These differences were not apparent at rest. Therapies targeting the haemodynamic compromise associated