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More and more countries utilize nurse anesthetists as an anesthetic care provider to make up for the insufficiency of anesthesiologists. To examine whether introducing nurse anesthetists with expanded scope of practice to anesthetic care would jeopardize the safety of patients and quality of anesthetic care. This observational study used an interrupted time series design. A metropolitan teaching cancer hospital located in Southwest China. 24290 patients with surgical procedures under general anesthesia from January 2015 to December 2017