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The aim The study is to research the resolution of perifocal brain tissue at various type strokes using immunomorphology. Materials and methods The immunohistochemical study of perifocal brain tissue in 21 cases of various strokes types was condacted. Results When comparing the GFAP + astrocytes detection area at IS, HS and IS with HT, no significant difference was found. At the 1st degree of GFAP + astrocytes were in the border around the necrosis nucleus at IS and IS with HT, and at HS GFAP + astrocytes accumulated along the hematoma