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COVID-19 is a viral transmissible disease where limited evidence exists on vertical transmission and prevalence of SARS-CoV-2 during pregnancy, birth, and postnatal period. The objective of this study was to evaluate the possible perinatal transmission of SARS-CoV-2 in mothers and neonates in a sample of Mexican population in a descriptive cross-sectional study. Methods. 133 nasopharyngeal swab samples from mothers, 131 swab samples from neonates, and 140 colostrum samples were obtained, and the presence of SARS-CoV-2 was determined by q