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001], but with greater reduction (≈3 beats/minute) in patients aged  less then  70 years. Resting heart rate and thoracic impedance showed minor variations. No differences were observed in device pacing % and arrhythmias. In cardiac patients, the lockdown imposed to contain COVID-19 outbreak significantly reduced the amount of physical activity and the mean heart rate. These side effects of in-home confinement quarantine should be taken in consideration for frail patients. The role of hypoalbuminemia and raised C-reactive protein (CRP)