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BACKGROUND As subarachnoid hemorrhage as a result of rupture of an intracranial aneurysm (IA) has quite an unhealthy result despite of a rigorous health care bills, development of a novel therapy concentrating on unruptured IAs on the basis of the proper knowledge of pathogenesis is necessary for social health. METHODS Using previously obtained gene expression profile data from surgically resected unruptured personal IA lesions, we selected G-protein coupled receptor 120 (GPR12 as a gene whoever e