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Specifically, SESCOD decreases from 2.71 × 102 to 0.16 × 102 kJ/g SCOD and specific energy decreases from 3.58 × 104 to 2.85 × 103 kJ/kg TS while DD values show reasonable values up to 17%. PRACTITIONER POINTS A new industrial hydrodynamic cavitation device has been developed to treat industrial wastewater without chemical additives A volume up to 500 L has been treated at industrial scale experiments. Sludge with 7% of total solids content was satisfactorily disintegrated. The process scale-up lead to an energy efficiency enhancement.Tanneries are