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Inside our previous researches we've identified T219A mutation into the E-protein of DENV therefore the current research is targeted from the impact of this mutation regarding the conformation of E-protein and also its binding variation with Abs and Fc-γ receptor. A comparative molecular modelling studies of crazy type and T219A mutant E-proteins disclosed that, the mutation induced a few conformational variations when you look at the E-protein and lead to the variab