https://www.selleckchem.com/pr....oducts/valproic-acid
Circadian differences in the induction, maintenance, or emergence from volatile anaesthesia have not been well studied. The minimal alveolar concentration (MAC) for preventing movement in response to a painful stimulus, MAC for loss of righting reflex (MAC ), and MAC for recovery of righting reflex (MAC ) in C57BL/6J male mice with isoflurane or sevoflurane exposure were measured during either the light or dark phase. Time to onset of loss of righting reflex (Time ) and recovery of righting reflex (Time ) upon exposure to 1 MAC of