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We suggest potential frameworks through which these functional cell types might support contextual processing. We then discuss deficits seen in humans who have damage to the homologous parahippocampal cortex, and we finish by reviewing functional imaging studies that found activation of this area while human subjects performed various tasks. A preponderance of evidence suggests that the POR, along with its interactions with retrosplenial cortex, plays a key role in contextual information processing. The phase III IMspire150 study (NCT02