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© 2020 Joule Inc. or its licensors.Leishmania major is the causative representative of cutaneous leishmaniasis (CL). No real human vaccine can be acquired for CL and current medication regimens present several disadvantages such as promising resistance, severe toxicity, moderate effectiveness, and/or large cost. Therefore, the need for better treatment plans against CL is a priority. In today's research, we validate the chemical methionine aminopeptidase-1 (MetAP1), a