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Various studies have revealed that psychological stress enhances pruritus.1,2 The COVID-19 pandemic have increased psychological stress. People may feel additional psychological stress in at-risk circumstances for the spread of COVID-19 infection. However, it is unknown whether at-risk circumstances for COVID-19, such as confirmed infection in acquaintances, are associated with the risk of pruritus. Thus, we investigated the association between at-risk circumstances and pruritus in the general population via cross-sectional and longitu