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Non-covalent adsorption and desorption of oligonucleotides on two-dimensional nanosheets tend to be extensively used to design nanobiosensors when it comes to fast optical detection of objectives. An exact control of the weak interactions between nanosheet interfaces and oligonucleotides is essential for a high-sensing performance. Herein, the interface of ultrathin WS2 nanosheets used as a fluorescence quencher was designed by four different dextran polymers in an aqueous answ