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98, 95% CI 0.97-0.99, P = .008).When the patients were classified by age, serum glucose levels were persistently lower in patients with PDPH vs those patients without PDPH in all age groups, with more clearly significant differences observed in the elderly (age 60 years, 111.8 mg/dL vs 137.3 mg/dL, P = .023). Conclusions Low glucose levels were inversely associated with risk for post-dural puncture headache. Patients with low serum glucose should be carefully monitored for headache after lumbar puncture.Vagus nerve stimulation (VNS) is