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analysis revealed that after introducing 5 other pollutants respectively, PM2.5, PM10, NO2, SO2 and O38h significantly increased the emergency room visits for respiratory diseases, and CO had a more obvious effect than that predicted with the single pollutant model. Conclusion The rises in the concentrations of six air pollutants in Lanzhou will increase the emergency room visits for respiratory diseases, and the patterns vary with different genders, ages and seasons.Objective To explore the function and mechanism of related genes in the