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CONCLUSIONS A multiple biomarker approach might be useful for predicting postoperative mid-term mortality in patients with severe AS undergoing SAVR. Further large-scale prospective validation should be performed. AJCC 8th Edition of Cancer Staging Manual has now incorporated depth of invasion (DOI) into the clinical staging of oral cavity carcinoma. This inclusion finds relevance as it opens the concept of 3rd dimension in clinical staging. Though a very thoughtful and necessary addendum into the cancer staging, its relevance and progno