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Girls' proactive approach yielded safer outcomes than boys' reactive strategy. To enhance their safety as pedestrians, girls adopt a proactive approach and select larger inter-vehicle gaps to cross into, whereas boys apply a reactive approach aimed at managing the risk created by having selected smaller (riskier) gaps. Girls' proactive approach yielded safer outcomes than boys' reactive strategy. Limited data are available regarding the effect of systemic therapy change in the post-cytokine era on survival of metastatic renal cell car