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Differences in feature values between time points were calculated for each feature, and logistic regression was used in conjunction with analysis of variance to classify patients with and without RP ( p 0.5 . Conclusions Radiomics features extracted using different software packages can result in differences in classification ability. © 2020 Society of Photo-Optical Instrumentation Engineers (SPIE).Purpose Placental size in early pregnancy has been associated with important clinical outcomes, including fetal growth. However, extraction