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Conclusion The findings of this study will exert evidence to judge whether or not HQNI is effective on anxiety and depression in patients with CHFM. Registration number INPLASY202040069.Rationale Eye rubbing (ER) is a proven factor that can trigger the onset and progression of keratoconus (KC). Apart from allergy, ER is a repetitive motor stereotypy. Eye rubbing is frequently observed in children with autism spectrum disorders (ASDs) and in individuals who may be at risk for developing KC. We present a child with ASD who developed progress
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