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The incremental gain in performance of a predictive model which included β3 integrin expression as quantified by IHC in combination with established clinicopathologic variables (Breslow depth and patient age) was limited. β3 integrin is the principal integrin subunit associated with sentinel lymph node biopsy (SLNb) metastasis in primary cutaneous melanoma. #link# However, β3 integrin H score does not significantly improve models for the likelihood of SLN metastasis over Breslow depth and patient age. β3 integrin is the principal integrin