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Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND The occurrence of secondary neurodegeneration has been exclusively observed after the first incidence of stroke. In humans and rodents, post-stroke secondary neurodegeneration (SND) is an inevitable event that can lead to progressive neuronal loss at a region distant to initial infarct. SND can lead to cognitive and motor function impairment, finally causing dementia. The exact pathophysiology of the event is yet to be explored. It