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omeTheus program is expected to result in higher function and mobility, greater independence and lower need for care, and more participation. As the PromeTheus program draws on existing German healthcare structures, its large-scale translation and delivery will be feasible, if evidence of (cost-)effectiveness and successful implementation can be demonstrated. German Clinical Trials Register, . Registered on March 11, 2021. German Clinical Trials Register, . Registered on March 11, 2021. Healthcare-associated infections are a major threat